Defense Regulation
Participants:
Carmen Beuzón López (PI), Javier Ruiz Albert (PI), Diego López Márquez
Collaborators:
Eduardo Rodríguez Bejarano (IHSM-UMA-CSIC), Peter Brodersen (University of Copenhagen)
About the line
In this research line, we analyse a regulatory mechanism in Arabidopsis based on gene silencing that contributes to controlling the expression of a broad network of TIR-NBS-LRR genes in the absence of pathogens, thus limiting the impact of constitutive defence gene expression on plant fitness. We investigate the expression of several components of the miR825-5p/MIST1/phasiTNLs regulatory module in different tissues and developmental stages of Arabidopsis, to determine its role in establishing immunity against Pseudomonas syringae.
Recent publications
- Rosa-Diaz I, Lopez-Marquez D, Beuzon CR, Diaz I. miR825-5p-regulated TNLs govern Arabidopsis resistance to Tetranychus urticae and Pieris brassicae. New Phytol. 2025 Jul 29. doi: 10.1111/nph.70411. Epub ahead of print. PMID: 40728092.
- López-Márquez D, Del-Espino A, Ruiz-Albert J, Bejarano ER, Brodersen P, Beuzón CR. (2023) Regulation of plant immunity via small RNA-mediated control of NLR expression. J Exp Bot. 2023 Jul 14:erad268. doi: 10.1093/jxb/erad268. PMID: 37449766.
- López-Márquez D, Del-Espino A, López-Pagán N, Rodríguez-Negrete EA, Rubio‑Somoza I, Ruiz-Albert J, Bejarano ER, Beuzón CR (2021) miR825-5p targets TIR-NBS-LRR gene MIST1 and downregulates basal immunity against Pseudomonas syringae in Arabidopsis. Journal of Experimental Botany. DOI: 10.1093/jxb/erab354
- López-Márquez D, Del-Espino A, Bejarano ER, Beuzón CR; Ruiz-Albert J(2020) Protocol: low cost fast and efficient generation of molecular tools for small RNA analysis. Plant methods. DOI: 10.1186/s13007-020-00581-w